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Wholesale Acetyl Tetrapeptide-22 Cosmetic Grade for Eye Serums
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Product Description
1. Mechanism of Action
Acetyl Tetrapeptide-22 is a biomimetic tetrapeptide specifically designed to target the primary causes of under-eye puffiness and dark circles. Its mechanism is multi-faceted and grounded in cellular physiology:
Targeting Periorbital Puffiness (Edema):
The peptide acts on the Vanillin Receptor Type 1 (VR1/TRPV1), which is involved in the perception of heat and pain and is also implicated in vascular permeability.
By modulating this receptor, Acetyl Tetrapeptide-22 reduces capillary hyperpermeability (leaky capillaries), which is a key factor in preventing the accumulation of fluid (edema) in the periorbital tissue that leads to puffiness and bags under the eyes.
Improving Dark Circles:
By stabilizing the capillaries and reducing leakage, it minimizes the seepage of red blood cells into the surrounding tissue.
This action subsequently reduces the breakdown of hemoglobin and the deposition of hemosiderin and other pigmented byproducts, which are major contributors to the bluish or brownish appearance of dark circles.
Anti-Inflammatory Action:
The peptide also exhibits anti-inflammatory properties by inhibiting the release of certain pro-inflammatory mediators, further helping to reduce swelling and discoloration.
2. In Vitro Efficacy Data
TRPV1 Receptor Antagonism: In vitro models demonstrate that Acetyl Tetrapeptide-22 effectively acts as an antagonist on the TRPV1 receptor, confirming its proposed mechanism for reducing vascular leakage.
Capillary Permeability Studies: Using endothelial cell cultures, the peptide was shown to significantly decrease vascular endothelial growth factor (VEGF)-induced hyperpermeability, validating its ability to "tighten" capillary walls.
Anti-Inflammatory Assays: The ingredient inhibited the production of key inflammatory markers such as PGE2 and IL-6 in cell-based models, supporting its role in calming the under-eye area.
3. Clinical Results
Study Design: A 56-day clinical study involving female volunteers with visible under-eye puffiness and dark circles. A formulation containing 5% of a solution of Acetyl Tetrapeptide-22 (corresponding to a few ppm of the pure peptide) was applied twice daily.
Key Findings:
Reduction in Puffiness: Clinical grading and instrumental 3D image analysis showed a significant reduction in under-eye bag volume and puffiness (up to ~30% improvement vs. placebo).
Diminishment of Dark Circles: Colorimetric analysis measured a visible lightening of the under-eye area, reducing the intensity of both bluish and pigmented dark circles.
Improved Skin Smoothness: The skin around the eyes appeared smoother and less fatigued.
High Consumer Satisfaction: The vast majority of participants reported a visible decrease in puffiness and a more refreshed, awake appearance.
Safety Profile
Excellent topical safety. Non-irritating, non-sensitizing, and non-cytotoxic at recommended use levels. Proven safe for use in the delicate eye contour area.
Biocompatibility
As a biomimetic peptide, it is well-tolerated.
Formulation Compatibility
*Highly soluble and stable in aqueous phases. *Compatible with a wide range of cosmetic ingredients, including other peptides (e.g., for wrinkles), caffeine, vitamin K, illuminators, and standard emulsion systems.
*Stable across a broad pH range and under standard manufacturing conditions. *Ideal for incorporation into eye creams, gels, serums, patches, and roll-ons.
*Stable across a broad pH range and under standard manufacturing conditions. *Ideal for incorporation into eye creams, gels, serums, patches, and roll-ons.
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Recommended Usage & Dosage
Recommended Concentration: 2 to 10 ppm (0.0002% - 0.001%) of the pure peptide.
*Note: Suppliers often provide a pre-diluted solution (e.g., 5% active). Formulators should calculate the final concentration of the pure peptide in the finished product.*
Typical Use Level: 5 ppm (0.0005%) is clinically proven to be effective.
Suggested Applications:
Primary: All types of eye contour products (creams, gels, serums, patches, masks).
Secondary: Any facial product targeting redness, puffiness, or capillary fragility.
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Precision Target
Used in formulations aimed at reducing dark spots, melasma, and overall skin discoloration.
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Mechanism-Driven
Its action on the TRPV1 receptor to reduce capillary leakage is a scientifically advanced and targeted approach.
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Clinically Proven Efficacy
Significantly reduces the appearance of bags and dark circles in vivo, helping consumers achieve a less tired, more refreshed look.
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High Potency
Delivers remarkable visual results at very low concentrations (ppm level), offering excellent cost-effectiveness.
Storage
Store in a closed container at a dry place at room temperature.
Animal Testing
Not animal tested
Vegan
Does not contain animal-derived components
GMO
No data available